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Showing posts with the label god

Why Do We Age?

Did you know that there are certain species on the face of the Earth that are truly and literally immortal? Yep. They never die. Of old age, that is. I am not talking about some microscopic bacterial life or stubborn viruses in existence. No. Real animals. Take these two: turtles and lobsters. They literally don't age. When it comes to first one, I can't resist not to quote article in below refs* I read online - to the logical suspicion of endless turtle lifespan and why in aftermath they don't crawl everywhere we look today, they answer: "Of course they die; otherwise we'd be swimming in turtles, but the weird thing is, they never seem to die of old age. It's always a disease, or a falling boulder, or Master Shredder". And this is a real truth, actually, including 'Master Shredder', who might be just a metaphor for us killing turtles for food or purses and belts or whatever we do with dead turtles. Joking aside, the very research of big turtles shows no evidence that their body change or mature after they pass teenage years. They are literally capable of sexual reproduction until the end of time. And again the glimpse from the noted article stating the obvious: "They can breed and lay eggs until the day they drop dead, and that means that, technically, a turtle can live and have sex forever". The same is with lobsters—well, I am not sure about the sex thing, but they don't age either. Just grow bigger and bigger and bigger until they finish their lifespan in the kitchen of some fancy restaurant. When they got so big that their shell couldn't sustain them anymore, they just got out and started growing a new one. I am sure somewhere out there in the bottom of some sea or ocean there are lobsters today old enough that are actually living witnesses of Darwin's "Beagle" sailing out for her historical voyage around the world in the early nineteenth century.


I am sure by now you already started growing an ultimate regret of why on Earth you weren't born on one of the Galápagos islands, hatched out from some egg, and spent eternity practicing marshal arts—and instead ended up being a human. But seriously, the title's question is real and open for scientific discussion. And for theatrical purposes, let me repeat it: "Why do we age?" And ultimately die? Surely, if we find out why, the next question is, of course, can we cheat it? Expand it? Live forever? If we find out that is possible, the third question in the row imposes. Should we do it?

But, before we dive into deeper thoughts and evaluate leading theories and hypotheses, I remember when I started with a blog, one of my early small posts in the humor thread was a couple of famous quotes about life itself. As far as I remember, many of them were really plain and intelligent jokes, but the one said by Ronnie D. Laing, a Scottish scholar who dedicated his life to research of mental illness and psychosis, was probably hitting the target in the bullseye. He said, "Life is a sexually transmitted disease, and the mortality rate is one hundred percent." If we extract the humor from this one-liner, what we really get is, perhaps, the ultimate truth. Reaching yours or mine old age, or death itself, might be nothing else than a genetic disease, in a stretched form of the definition of the word 'disease', and we might be able to do something about it.


Well, contrary to lobsters and turtles (and some other 'immortal' species like certain types of whales, seashells, sponges, hydras, etc.), we are mammals, pretty different kinds of anim... ahem, species. We are different in many ways, genetically speaking and comparing to, for example, reptiles; we cannot re-grow our teeth or entire body parts as well, and our DNA, as it seems, has limited regeneration ability that fades with years and ultimately gets exhausted the moment before death. For those lucky to die of old age.

Two leading theories have been posted until today. First, it was proposed that living organisms have some sort of genetic expiration time, written in DNA. In other words, we are all combinations of genes of our parents and their parents and parents before them, all the way back in the history of our families, and this lucky mixture of genes, written in all of our cells, is built to last only a limited period of time. Even though this theory seems so unbelievable and far-fetched, it is actually hinted in labs. In some genetic research of worms, altering their genome and some specific genes 'produced' the worms who actually lived four times longer than their unaffected peers.


If those genes with encoded expiration dates really exist, finding and rewriting them might be able to increase our lifespans. However, the second theory is much more appealing and easier to understand. It simply says that our cells die at the end of the cycle due to too much damage they suffer over time. To simplify it, there are two types of DNA in our cells: nucleus DNA, which defines us, located in the cores of cells, and mtDNA, residing outside the nucleus and in special parts of the cells called mitochondria. While nucleus code is used during the cell's division to produce another cell with the same DNA, mtDNA is there mainly to produce energy for the cells from the food we consume. And both DNAs can be damaged over time due to various factors, and as time passes over years and decades, the damages become more severe, and at the end of the process, we know as aging, the entire organism dies. If we focus on mtDNA first, it's logical that these 'power plants' of our cells endure way too much pressure than their fellow DNA in the nucleus, as they are in the first front lines hit by influences of the food we eat. From that food they produce energy and, in the process, a very bad byproduct called ROS, 'Reactive Oxygen Species', which are a variety of oxygen-based molecules that are very dangerous for the power plant itself and very capable of ultimately damaging the cell and mtDNA to the point of full destruction in the process of unwanted mutations. Basically, if you are now thinking that a special sort of diet or simply eating less food would give you a longer life, think again. In fact, if you do so, it is logical that more DNA in mitochondria will survive over time in their intact form, but on the other side, restricted diet in lab animals shows that they grow slower than normal, reproduce less than normal, and have endangered immune systems than usual. We need food. It is essential. So, don't stop eating, but try to do it properly and in the most healthy way possible. But the theory of lifespan directly related to the healthy mtDNA is proven in poor lab mice in which scientists encoded a faster genetic mutation of mitochondrial DNA, which resulted in faster aging and a shorter lifespan—they actually lived three times shorter than their 'normal' friends and cousins. So oxygen is bad and ultimately kills you. And yet we cannot live without breathing, can we? A paradox of creation, especially if you are a believer.

What about nucleus DNA in our cells? Are they also causing aging in the process of mutation? Yes, due to mutation of nucleus, DNA cells end up in a cancerous or non-cancerous state, which is pretty much a defect and cell's death. During an organism's growth, cells divide in the process called 'mitosis' - one cell by using code in the nucleus, DNA divides into two new cells, which are exact replicas of the parent cell. Even after an organism has fully matured into its adult stage, cells still continue to divide for the purposes of reproduction and replacement of lost or dead cells. However, as it seems, both resulting cells are not really and exactly the same as their predecessor cells. Yes, the code in chromosomes is the same, but the ending caps of the chromosome structure are getting shorter after each division. These caps are called 'telomeres' and their main purpose is to protect the end of the chromosome from connection with other chromosomes. After numerous divisions of the cells, telomeres run out, and this is pretty much the end of it. The cells are after that doomed. But this is not the end of all the ways of one cell doomsday scenario. According to Aubrey de Grey, one of the leading scientists in biogerontology, the scientific sub-field of gerontology concerned with the biological aging process, over the years the cells accumulate various molecules that are no longer useful and potentially harmful. And not just within the cells, but also in the space outside cells. Those molecules are scientifically called 'intracellular and extracellular aggregates' but their real names are 'junk molecules' and, like the name suggests, the more of an accumulation of junk, the more dysfunctional the organism becomes. Dr. Aubrey de Grey proposed even more processes, on the cell level, influential in aging, and thanks to his research and the entire scientific mainstream, which is still ongoing research, we definitely understand it more than ever.


Benjamin Franklin once said that in this world nothing can be said to be certain except for death and taxes. I, for one, would definitely like to see the end of death and taxes for sure, and even though it is very hard to imagine a world without taxes, the death after all might be a very different story. Well, understanding the aging is one thing, and finding the cure for it is surely another, not to mention manufacturing a 'cheating-death' pill is not really in the realm of possibility anytime soon. Even the 'genetic pill' that will be able to slow down aging or the one capable of reverse engineering that would replace the mythical fountain of youth (or Lazarus Pit from the DC Comics franchise) are far away from the horizon. However, what is on the horizon and even much closer is the effort and research. Last year Google announced a plan to invest lots of money into California Life Company, aka Calico, and if you go to their website, the first thing you will see is their motto, "We're tackling aging, one of life’s greatest mysteries." If you dive into the current stage of IT-leading entrepreneurs and futurists, it seems they all are sharing the same enthusiasm in the "curing death" realm, and I can't help myself but stating similarity with A.G. Riddle's new novel called "Departure", which pretty much influenced me to write this post, even though I was planning it for a while. I will not spoil the reading for you, but in the nutshell, one of the background story in it is dealing with immortality which, in one way or another, resulted in end of civilization as we know it. I am encouraging you to read the book; it is definitely one of the best novels of the year in the sci-fi realm. In short and in the aftermath related to immortality, one of the leading characters from the novel, Sabrina Schröder, was portrayed giving a TED talk about cheating death and why we should avoid it in great scales. That's all I would say. Sorry, but you would have to read the entire book to understand everything. I will just say that I hope Riddle's 'Titans' are not predictions for 'Googlers' or 'Applers' or 'Calicos' or whatever the name they come up with in the upcoming breakthroughs in aging research.

As for me, I am sure I wouldn't mind prolonging life a bit, or a little bit, or a 'frakking' long bit, but avoiding death is raising lots of other dilemmas in morality and everything else. It could be handy on long interstellar voyages, though, but it is not far from the truth that reproducing and further evolution of humans would be in real danger if everybody took the immortality pill and if we stuck in the current stage of evolution without offspring of any kind. Morality issues of a potential cloning of a human being and making it immortal might not be too different.


Extending the lifespan is a very different story. I would always take the red pill and jump into the rabbit hole without hesitation. The life is way too short. After all, lifespan is something nature and evolution have been working on for centuries. If we learn to push and help a little with science, I would definitely be aboard.

Refs:
http://www.calicolabs.com/
http://www.medicaldaily.com/cure-aging-google-plunks
http://www.telegraph.co.uk/.../trying-to-cure-ageing.html
https://en.wikipedia.org/wiki/R._D._Laing
http://genetics.thetech.org/original_news/news10
http://www.todayifoundout.com/index.php/2014/05/age/
http://www.agriddle.com/departure/sabrina
http://www.agriddle.com/Departure
* http://www.cracked.com/animals-that-are-immortal.html
http://www.aboutdarwin.com/voyage/voyage03.html

Image credits:
http://nocamels.com/2013/12/stop-aging-to-prevent-alzheimers/
http://nocamels.com/2015/06/genetic-sequencing-evolution-cancer-brca1/

Constantine & Naissus

A couple of centuries after Christ, Constantine was a very popular name. Especially among soldiers in the Roman and Byzantine empires, along with Greeks during their Macedonian age. Within Latin, Cōnstantīnus, and Greek, Κωνσταντῖνος (Kōnstantînos), the name literally means the one who's constant and steadfast, especially within military properties related to strength and stamina. In those times the land of my current location was called Moesia Superior, with the city of Naissus in the role of its main trade center and biggest military outpost for the Roman army. Today's name of the city is "Niš", the largest city of southern Serbia and also the city where I was born and where I have lived ever since. The Serbian usage of the name is "Konstantin", and even though it is not related to the the military anymore, the name is fairly popular nowadays among young Serbians. It was third on my list when my son was born simply because I really like names with strong inner "adjectivity" and history as well, but in our case my son's name, Viktor, won six years ago in the photo finish. If I had another son, his name would probably be Konstantin (Constantine) or Filip (Philip), but now it is certain that this will stay in my wish list only.

Constantine the Great*

Well, this post is not going to be just about names. Instead it will be equally about my birth town, the history of the Christian religion and the "Edict of Milan", a small glimpse of the Roman Empire, the end of the Classical era during violent events in ancient Alexandria, and a little photography along the way. But, for a moment, let's stay with names and their importance for this story. With mention of the "Edict of Milan", the city I was most probably named for, many of you probably guessed why I partly named this post "Constantine". Constantine I, or Constantine the Great, emperor of the western part of the Roman Empire, and Licinius I, his fellow emperor of the eastern part, in February of 313 BC, declared Christianity, the rising religion of the time, to be treated equal to all other official beliefs in the whole of southern Europe, northern Africa, and a big portion of eastern Asia ruled by Romans after the Crucifixion of Jesus, where the modern history we are living in started. But the early days (or, to better say, centuries) of "modern history", or what we love to call "AD," were, to call it the least, very disturbing. The probably best example of those violent "multi-religious" times happened at the end of the fourth century in the city of Alexandria. I am sure if Alexander the Great knew what would happen 700 years after he founded the city, he would never do it in the first place. In the classic BC times of great cities, free thought and scientific premises flourished in the most famous institution in the world at the time and probably ever since—the great Library of Alexandria. In those times, over a million scrolls from Assyria, Greece, Persia, Egypt, India, and many other nations were stored in the library, and comparing it to nowadays terminology, we can safely say that the entire ancient "internet" was located within one single library. More than a hundred scholars worked full-time within the library's walls, performing research, translating documents, giving lectures, and writing books. It was one of the shiniest periods of the whole world's history.

Then "Anno Domini" happened. Soon after the birth of Christianity, Alexandria became home for people of different beliefs but mainly Christians, Jews, and Pagans. One ancient writer claimed that there were no people who loved a fight more than those of Alexandria. Religious animosities rose to the edge in the time of Theophilus, Patriarch of Alexandria, and in his raid, around 391 AD, the Temple of Serapis, where one branch of the Alexandrian library was located, was demolished, documents were destroyed, and the temple was converted to a church. The rest of the library's treasure was probably lost a couple of years later when one of the most famous women who ever lived, Hypatia, a Neoplatonist philosopher, mathematician, and astronomer, was killed by Christians during some retaliation against both the Jews and the Pagans. That night was officially the end of Classical antiquity, or the era of prosperity I was talking about in the post Aegean Sea. If some document survived that night, when Hypatia was stripped, beaten, and hacked to pieces and her body burned to hide all traces of the crime, then it was destroyed centuries later, when Muslims took the city of Alexandria around the year of 640 AD, where all the remaining scrolls were proclaimed either heresy or superfluous.

Rachel Weisz as Hypatia of Alexandria in Agora (2009)

There is no doubt that Constantine the Great was one of those great visionaries who foresaw all possible futures of the Roman Empire and had enough courage to act and officially acknowledge the definite rise of Christians in order to avoid all the dangers that came with the first multicultural societies. Rome and Constantinople under his rule and the rules of many emperors that came later more or less managed to survive Alexandria's fate. At least until a couple of centuries later when the third big player in the world of monotheistic religions appeared in the face of Islam. We all know what happened next. The Crusades. What happened to Alexandria in the fourth century started to happen to Jerusalem. Multiple times. During each crusade. Some would say it is not over yet.

If the story so far was not enough to demonstrate the cruelty of the first couple of centuries of the first millennium AD, I have some more historical facts, and they all originate way back to the point of the first founders of my hometown. The misfortune of Naissus was in the fact that its location was on the crossing road point between north and south and west and east. Whoever the warrior you were and whatever army or tribe you belonged to in those times, your path would lead through Naissus, and you were destined to raid it, no matter if you were a member of the Triballi tribes who invaded this area in the 4th century BC, a member of the Gallic groups who invaded the Balkan Peninsula during the 3rd century BC, or a Roman who gave the original name to the town and held it the longest period of them all, but with the price of thousands of men lost in numerous battles, with the most famous one called simply "Battle of Naissus", where Romans with the help of Dalmatians and Greeks finally defeated the enormous invasion by Goths and their allies. Later in the 5th and 6th centuries, the town was constantly in flames and devastated by Attila's Huns and barbarians, restored by Romans and Byzantine emperor Justinian I, and then demolished again by Avars and finally occupied by Serbian ancestors, the Slavs, in the year 540 AD or so. Serbians managed to hold it even longer than Romans, all the way into the next millennium, but also with frequent interruptions by various invasions in the face of Bulgarians and Ugri (Hungarian ancestors). The second millennium was no different, and the same area where I am sitting right now was under different rulers: firstly by Byzantine forces, the Hungarian kingdom, Greeks, Serbians again, the Ottoman Empire, Austrians... Phew... I probably forgot someone. Let's just finish with all the world wars, Germans, and the Nazis and hope that all the testosterone in the third millennium has devolved a little and we will witness no more wars like before.

Third-century Roman soldiers battling Gothic troops**

Naissus was a birth town for three Roman emperors in the 3rd century and after. The most famous one was of course, Constantine the Great (272), but also Constantius III (360) and later Justin I (450). Within the suburb of Naissus, not far from the thermal water spa, during the reign of Constantine the Great, Romans built a luxurious residence with a highly organized economy by the name of Mediana***. Until it was fully destroyed by Attila's hordes in the year 442, the residence was used by several emperors after Constantine, including Julian the Apostate, who was best known for his attempts to restore paganism to the Roman Empire, and this time within Hellenistic polytheism (Julian was also one of the Neoplatonist philosophers, like Hypatia), and for several edicts in various laws, including the Tolerance Edict of 362. Obviously, his efforts were not successful for a longer period of time, and religions with gods seen in plural finally ended in Greek and Roman mythology and picturesque legends. But, perhaps the best-known role of the residence of Mediana, which is, by the way, only a couple of hundred meters from my home, was in the year 364 AD, when emperors Valentinian and Valens met there and divided the Roman Empire and ruled as co-emperors.

Well, in the history of humans, every separation between west and east was never without serious consequences. The separation of the Roman Empire, over time, moved the center of power from Rome to Constantinople, starting with Rome's fall on September 4, 476. The Christian Church suffered the same. Distance and differences did the math, and the Church finally separated in the so-called "Great Schism", culminating in the early 11th century and giving birth to the Eastern Orthodox Church and the Roman Catholic Church we all know today. The saddest thing is that one full millennium has passed since then, and both "grand" fractions of the same religion are still looking at each other over their shoulders. After all that time, I am positive that if we randomly select one Catholic cardinal and one Orthodox patriarch and ask them why the Church split up in the first place and why they didn't manage to even sit and talk for 1000 years and find the way to "un-schism" the lost millennium, I am sure that they would hardly be able to provide any meaningful answer. Giving up the throne is never easy, and I guess the only way to unite Christianity is for God to show himself once again and to cut the misery once and for all. But, this story is not the place for me to express all of my skepticism about this, and if you are eager to read more about my religious glimpse of the world, please go to Science of God.

In front of Church of the Holy Emperor Constantine and Empress Helena

Well ok, let's stop with history now and continue with some more cheerful stories. For starters, please allow me to quote my favorite character from the movie "Kung Fu Panda". In the animated story, Master Oogway, among all his turtle wisdom, said exactly this: "Yesterday is history, tomorrow is a mystery, but today is a gift. That is why it is called the present." It is a beautiful one-liner, and after a little search online, I have to say that I failed to find the origin of this quote, but I am perfectly fine to credit it to Oogway himself. In that spirit, let's switch from history to the present and talk a little about my home city and the religious event happening this weekend.

This year is the 1,700th anniversary of the Edict of Milan, and this weekend is chosen in Serbia to be memorialized with special liturgy (λειτουργία), where all major patriarchs gathered in Niš, or Naissus if you will, to honor Constantine's efforts to stop persecuting Christians and give the rising new religion a chance to be equal with others. The liturgy took place in front of the Church of the Holy Emperor Constantine and Empress Helena in one of the biggest parks in the city, and for this occasion a piece of wood from Jesus's cross (fragmentary remains that are by tradition alleged to be those of the True Cross) and John the Baptist's right hand, with which he baptized Jesus, were transferred to Constantine's new church. Last night, two relics were moved to the new display, and we wanted to feel the atmosphere. The crowd was fantastic, and on the nearby cross section people formed the cross with candle lights in total darkness (below photo), while this morning was the official event for "VIPs", which was much less interesting. Perhaps the only shadow to the occasion was the presence of a zillion policemen fully armored and spread everywhere. I guess they will never learn that the same job can be done without uniforms and with hidden guns, but that's a topic for another story.

1,700th anniversary of the Edict of Milan in Niš, Serbia

After 1700 years, I guess lots of things changed. There is no Roman Empire anymore or big crusades, but religiosity is still there, without much disturbance by the passed centuries. We can say about the Christian church in general whatever we want, but one thing is for sure. A society of people can't live without protocols and rituals. This is what we are, and I will just repeat what I said two years ago in relation to Orthodox Christian rituals: "From the point when we are born until we die, there are many occasions requiring many events to be performed. I mean, I can't imagine a wedding here in Serbia without the church involved. They have very nice protocols. Funerals too. Anything that requires more than two people to participate with, religious organizations are doing this just right."

They proved it once again.

Image ref:
https://philipstanfield.com/tag/mysticism-2/

* Constantine the Great
https://relevancy22.blogspot.rs/2015_03_02_archive.html

** Battle of Naissus
http://www.crystalinks.com/CrisisoftheThirdCentury.html
http://en.wikipedia.org/wiki/Battle_of_Naissus
http://artnumisma.com/2013/05/20/battle-of-naissus-268ad/
http://www.geocities.ws/reginheim/battles.html

*** Mediana
http://www.panacomp.net/serbia?mesto=srbija_medijana
http://en.wikipedia.org/wiki/Mediana

More references
http://www.math.wichita.edu/history/women/hypatia.html
http://upload.wikimedia.org/wikipedia/commons/b/bb/Roman_Empire_125.png
http://en.wikipedia.org/wiki/Constantine_the_Great
http://en.wikipedia.org/wiki/Niš
http://www.ni.rs/index.php?language=en
http://en.wikipedia.org/wiki/Edict_of_Milan